UltraVector®

UltraVector®: The key to rapid development and customization
Platform
Powering the next generation of synthetic biology solutions

The UltraVector® platform is an operating system comprising advanced DNA construction technologies, cellular and protein engineering, computational models and statistical methods which facilitate the rapid design, testing and production of complex biological systems. In addition to hosting all of the design, build and testing capabilities within one cohesive platform, UltraVector® learns by amassing a wealth of data over iterative experiments in this process.  The UltraVector® platform is also capable of incorporating supplementary technologies, which can be selectively utilized depending on the desired biofunction.

Intrexon is continually designing and employing components that provide more precise control over genome integration and gene regulation, such as the RheoSwitch Therapeutic System® (RTS®) technology. RTS® technology enables inducible regulation of gene expression through administration of a small molecule ligand and can control the concentration and timing of expression to achieve a biological outcome.

Other components include our AttSite® recombinases, which facilitate rapid integration of DNA into predictable or targeted genomic locations to achieve stable gene activity over time. This tool eliminates many of the difficulties associated with traditional gene insertion, which is often difficult to perform and can result in unpredictable outcomes.


Application
The Operating System for DNA Solutions

The goal of synthetic biology is to engineer and introduce the appropriate genetic components that will yield a product with the desired outcome, such as enhanced biological function, decreased cost of goods or therapeutic effect. In order to quickly and effectively optimize a product, more is needed than just DNA parts. Through the UltraVector® platform a wealth of data has been captured over iterative experiments in the design, build, and testing of DNA components. We have characterized these components and how they function together, knowledge that drives more efficient engineering of biological systems. Intrexon’s UltraVector® platform is an operating system which enables us to advance beyond DNA manufacturing, generating not only the parts but also end-to-end solutions for product development.

It is often necessary to explore multiple variables simultaneously to develop the best biologically-based products.  Testing such a broad sample set simultaneously for positive traits requires several integrated capabilities:
 
  • Software and database systems to capture the design intent and performance data of characterized genetic parts and combinations of parts
  • A powerful set of statistical tools to guide efficient sampling of a large biological sample space
  • High-throughput screening capacity matched to library requirements
  • A suite of analytical methods to enable recognition and then recombination of improved performers.
 
Our UltraVector® platform encompasses all of the above requirements to facilitate the rapid design, build and testing of complex systems. The UltraVector® platform allows us to translate complex gene programs into standard components that can be designed, manufactured and tested in a robust, automated format. This technology enables us to engineer at the cellular level from biological sources.
Function
True Commercial Scale

The UltraVector® driven build is automated, modular, and utilizes a proprietary set of defined construction rules to rapidly assemble gene programs from our library of characterized genetic components. The underlying engineering helps determine the best approach to efficiently assemble DNA, regardless of complexity or scale, providing our collaborators with multiple options for efficiently optimizing DNA-based solutions. These construction rules are derived from UltraVector’s DNA programming language that supports the standardized assembly of DNA parts. Our expansive library of genetic components with its associated database of performance data, combined with automated engineering, enables the rapid assembly of gene programs to accomplish desired biological outcomes at true commercial scale.

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