Porcine Research Models

Intrexon has the ability to develop custom miniature swine models of human genetic disease to enable therapeutic discovery through its wholly owned subsidiary Exemplar Genetics.  Miniature swine represent a powerful investigational platform since they are anatomically similar to humans and surpass many of the limitations of murine systems, including lack of translation and differences in size and metabolism.

Utilizing its proprietary technologies in animal genetics, Exemplar has developed a broad pipeline of transgenic swine models for research on heart disease, cancer, cystic fibrosis, cardiac arrhythmia, neuromuscular and neurodegenerative disorders.  ExeGen LDLR-/-&+/- is the Company’s most advanced porcine model designed to empower superior drug and device discovery in the area of cardiac disease.  Exemplar’s leading technologies and expertise provide the necessary infrastructure to facilitate humanized large animal disease model development and characterization to enable better predictive power in the generation of novel gene- and cell-based therapeutics and biologics for a range of disorders for Intrexon’s channel partners.
 
Learn more about porcine research models in the Scientific Literature section and by visiting Exemplar’s website.