Technology
Intrexon's technology platform employs DNA as the natural control modality for the reprogramming of
living cells and their corresponding application to a wide range of life science challenges and opportunities.
Our RheoSwitch® and activator ligands, AttSite® integrases, and T-Domain Modulators™ enable key DNA
control capabilities, from pre-transcription to post-translation:
- Integration — Stable integration of controllable expression systems into preferred genomic loci for safety and transcriptional viability.
- Induction — Activation of bio-molecular expression can be timed to occur once a transduced cell is in a desired state and/or target location.
- Level — Amount of expression can be regulated by the dosing levels of an external activator ligand and conditionally in concert with cellular factors.
- Duration — Duration of expression can be tightly managed using the activator ligand, including OFF.
- State — Cell type, developmental stage, receptor status, and other state-specific conditions can be used to regulate expression levels.
- Location — Constraint of biologics to predetermined locations to limit or eliminate off-location toxicity effects and enhance performance/efficacy.
Intrexon uses its proprietary UltraVector® platform to design, produce and optimize controllable gene systems based on targeted applications and outcomes. UltraVector® is an advanced, modular genetic engineering system that is capable of rapidly generating large quantities of combinatorial DNA candidates for high throughput testing, analysis and lead selection. Important advantages of UltraVector® include:
- Interoperability — Standardized molecular architecture enables intrinsic interoperability and flexible swapping of parts and sub-assemblies.
- Rational Reuse — Proven and novel DNA parts and sub-assemblies can be intelligently reused in many different vector combinations.
- Less Variability — in silico design algorithms and annotations, coupled with reuse of proven
parts, reduces manufacturing and performance variability.
- Scalability — Hierarchical parts schema enables scalable combinatorial assembly for high throughput screening of biological effects.
- Cost Savings — Modular approach shifts the paradigm from slow craftsmanship to rapid flexible design and assembly, resulting in substantial cost savings.