Senior Director, T cell Receptor (TCR)

We are seeking a highly motivated and creative Senior Director with experience in T cell biology, primarily for T cell receptors (TCRs) identification and chimeric antigen receptor generation (CARs) and TCR/CAR T cell analysis to join Intrexon’s Immunology Division in Germantown, Maryland. ImmunoOncology is a rapidly growing and exciting area of cancer therapy, with the promise to revolutionize the way patients are treated. This position will assist in the development of various therapeutic modalities for the treatment of patients with cancer. The successful candidate will have an in-depth understanding of T cell biology and immunotherapy and experience in leading teams and programs.


Job Snapshot:
Posted On:
Location:Germantown, MD
Department:Immunology
Job Type:Full Time
Education:Ph.D. in Immunology with expertise in T cell immunobiology and/or tumor immunology
Experience:Seven (7) or more years post-doctoral experience, industry experience a plus working in a dynamic team environment with a solid track record in cancer immunotherapy research and/or development.
Reference Id:1359
Travel Required:Minimal
Manage Others:Yes
 
Description:
DUTIES AND RESPONSIBILITIES:
  • Supervise research associates and/or scientists.
  • Work with multiple teams to effectively advance research programs efficiently.
  • Demonstrated ability to lead others.
  • Manage timelines and deliverables.
  • Develop reports for various projects.
  • Employ screening strategies for identifying tumor antigens, cloning T cell receptors and genetic modification of human T cells with TCRs and CARs specific for antigens expressed by malignancies.
  • Setup the evaluation strategy using in vitro studies with human T cells and in vivo murine models to test novel adoptive T cell therapies.
  • Perform correlative studies to evaluate the transfer, persistence and function of antigen-specific T cells in human clinical trials of adoptive T cell immunotherapy. 
  • May also participate in the laboratory evaluation of clinical trials involving engineering of peripheral blood stem cell grafts for improved allogeneic hematopoietic stem cell transplantation outcomes, and in the development of future immunotherapy strategies.
  • Exceptional communication skills in both oral and written form.
  • Utilization of appropriate technology, i.e. Outlook, PowerPoint, and other programs to create and distribute reports and key information.
  • Coordination of parallel tasks across multiple projects, demonstrating prioritization.
  • Interpret and effectively execute upon a variety of instructions provided in written, oral, diagram or schedule formats.
  • Self motivated and independently minded.
  • Positive interpersonal skills with the ability to interact with individuals from a variety of levels and function.
  • Self-organizer, meticulous hands-on habits, keen attention to detail.
  • Strong quantitative and analytical skills.
  • Responsive, can-do attitude.
SUPERVISORY RESPONSIBILITIES:
  • 1 - 3 Research Associates/Scientists
EDUCATION AND EXPERIENCE:
  • Ph.D. in Immunology with expertise in T cell immunobiology and/or tumor immunology
  • Seven (7) or more years post-doctoral experience, industry experience a plus working in a dynamic team environment with a solid track record in cancer immunotherapy research and/or development.
  • Direct hands on experience with identifying, generating and analyzing T cell receptors and/or chimeric antigen receptor (CAR) T cells. 
  • Experience with next generation sequencing analysis an asset.
  • In-depth understanding of:
    • TCR mediated signaling and antigen presentation and recognition
    • Inhibitory and co-stimulatory molecules and their associated signal transduction pathways
    • T cell subsets and surface markers - Teff, Tmem, Treg Th1, Th2 etc.
  • Demonstrated experience in the following techniques:
    • PCR, cloning, vector design and Westerns, as well as, flow cytometry, ELISPOT, target cell killing assays, cloning, vector design and cell culture. 
DESIRED KEY COMPETENCIES:
  • Ability to understand and execute on the company’s mission and values.
  • Maintain a high degree of ethical standard and trustworthiness.
  • Capable of fostering change in an organization.
  • Deals with conflict in a direct, positive manner.
  • Ability to think and adapt to a rapidly changing environment and demands.
  • Able to reach rational conclusions through complex processing of information.
  • Fosters innovation through creative solutions.
  • Effective organization and implementation of group projects.
  • Maintain a high degree of accuracy and attention to detail.
  • Energized by accomplishments and excellence in the workplace.
  • Capable of high performance in independent work as well as in team setting.
EOE MFDV